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US 12,383,692 B2Granted
Systems and methods for synthesis of nitric oxide
AssigneeThe General Hospital Corporation
InventorsWarren Zapol, Binglan Yu
Life of this patent
Estimating the term…
Abstract
Systems and methods for producing nitric oxide (NO) to be used in medical applications are provided. In some embodiments, systems and methods are provided for a NO generator that is capable of generating a desired concentration of NO to be provided to a respiratory system for inhalation by a patient.
Claims18
An apparatus for generating nitric oxide comprising:
- one or more pairs of electrodes configured to generate a gas comprising nitric oxide from a fluid flowing to the one or more pairs of electrodes;
- one or more sensors configured to measure at least one of a pressure, a temperature, and a humidity of the fluid flowing to the one or more pairs of electrodes;
- and
- a controller in communication with the one or more pairs of electrodes and the one or more sensors and configured to supply an electrical signal to the electrodes that controls timing and sparking characteristics of the one or more pairs of electrodes to produce a concentration of nitric oxide generated by the one or more pairs of electrodes, the controller being configured to determine the timing and sparking characteristics based on measurements from the one or more sensors to generate a desired concentration of NO,
- wherein the controller is configured to determine the timing and sparking characteristics by controlling a value of one or more of a number of spark groups per second (B), a number of individual sparks per group (N), a time between individual sparks (P), and a pulse duration of each individual wave in the spark group (H) based on the measurements from the one or more sensors,
- wherein the controller is configured to calculate the value of the one or more of the B, N, P, and H using a model for generating the desired concentration of NO using the measurements from the one or more sensors.
3 more elements
An apparatus for generating nitric oxide comprising:
- one or more pairs of electrodes configured to generate a gas comprising nitric oxide from a fluid flowing to the one or more pairs of electrodes;
- one or more sensors configured to measure at least one of a pressure, a temperature, and a humidity of the fluid flowing to the one or more pairs of electrodes;
- and
- a controller in communication with the one or more pairs of electrodes and the one or more sensors and configured to supply an electrical signal to the electrodes that controls timing and sparking characteristics of the one or more pairs of electrodes to produce a concentration of nitric oxide generated by the one or more pairs of electrodes, the controller being configured to control the concentration of nitric oxide generated by the one or more pairs of electrodes by controlling one or more of a number of spark groups per second (B), a number of individual sparks per group (N), a time between individual sparks (P), and a pulse duration of each individual wave in the spark group (H) based on the measurements from the one or more sensors,
- wherein the controller is configured to calculate the B, N, P, and H using a model for generating a desired concentration of NO with measurements from the one or more sensors.
2 more elements
Dependencies are inferred from the claim text.