Tissue engineered intestine
AssigneesResearch Institute At Nationwide Children's Hospital, Nanofiber Solutions, LLC
InventorsGail E. Besner, Yanchun Liu, Jed Johnson
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Abstract
The invention provides for engineered intestinal construct and methods of making these constructs. The invention also provides for methods of treating short bowel syndrome or methods of repairing an intestine after resection comprising inserting an engineered intestinal construct into the intestine of a subject in need.
Claims8
An engineered intestine construct comprising a nanofiber scaffold seeded with neural stem cells, smooth muscle cells and intestinal stem cells from intestinal crypts, and wherein the nanofiber scaffold comprises HB-EGF polypeptide or a fragment thereof.
An engineered intestine construct comprising a nanofiber scaffold seeded with neural stem cells, smooth muscle cells and intestinal stem cells from intestinal crypts, wherein at least one of the neural stem cells, smooth muscle cells or intestinal stem cells overexpress HB-EGF polypeptide or a fragment thereof.
An engineered intestine construct comprising a multilayer nanofiber scaffold,
- wherein the multilayer nanofiber scaffold comprises at least an inner layer and an outer layer,
- wherein the outer layer comprises neural stem cells and smooth muscle cells, and
- wherein the inner layer comprises intestinal stem cells.
Dependencies are inferred from the claim text.