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US 12,383,628 B2Granted
Hydrogel-forming composition for controlled release
AssigneesVrije Universiteit Brussel, Universiteit Gent
InventorsCharlotte Martin, Annemieke Madder, Steven Ballet, Richard Hoogenboom
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Abstract
The present invention provides peptide hydrogelators capable of forming hydrogels as carriers of active ingredients and acting as sustained or controlled release drug delivery systems.
Claims23
An injectable biogel composition for controlled release of a biologically active ingredient, comprising:
- an amphipathic peptide hydrogelator comprising at least 4 and at most 16 amino acid residues;
- wherein the amphipathic peptide hydrogelator comprises alternating hydrophobic and hydrophilic amino acids;
- and
- one or more biologically active ingredient(s),
- wherein the amphipathic peptide hydrogelator and the one or more biologically active ingredient(s) are covalently coupled, optionally by a linker, and
- wherein the covalent bond between the covalently coupled amphipathic peptide hydrogelator and the one or more biologically active ingredient(s) is biodegradable, and
- wherein the injectable biogel comprises of beta-sheet assemblies of the amphipathic peptide hydrogelator.
4 more elements
Dependencies are inferred from the claim text.