Plasmodium sporozoite NPDP peptides as vaccine and target novel malaria vaccines and antibodies binding to

A recombinant nucleic acid molecule comprising:

• (i) a polynucleotide encoding an antibody, or an antigen-binding fragment thereof, that is capable of binding to a Plasmodium falciparum sporozoite, wherein the antibody, or the antigen-binding fragment thereof, comprises:
• a heavy chain variable region (VH) comprising a CDRH1, a CDRH2, and a CDRH3, the heavy chain variable region (VH) having an amino acid sequence, the amino acid sequence consisting of SEQ ID NO:
• 248;
• a light chain variable region (VL) comprising a CDRL1, a CDRL2, and a CDRL3, the light chain variable region (VL) having an amino acid sequence, the amino acid sequence consisting of SEQ ID NO:
• 249;
• an IgG1 Fc moiety comprising:
• a heavy chain amino acid sequence, wherein the heavy chain amino acid sequence is according to SEQ ID NO:
• 313;
• and
• a light chain amino acid sequence, wherein the light chain amino acid sequence is according to SEQ ID NO:
• 314 or 315;
• and
• (ii) a promoter sequence.