Materials and methods of using an inhibitor of plasminogen activation to treat anastomotic leak
AssigneesThe University of Chicago, Rush University Medical Center
InventorsJohn C. Alverdy, Olga Y. Zaborina, Richard A. Jacobson
Life of this patent
Estimating the term…
Abstract
Disclosed herein is the de novo synthesis of phosphorylated polyethylene glycol compounds with three defined ABA (hy-drophilic/-phobic/-philic) structures: ABA-PEG10k-Pi10, ABA-PEG16k-Pi14, and ABA-PEG20k-Pi20 and linear polymer PEG20k-Pi20 absent of hydrophobic block. The disclosure also provides materials and methods for treating or reducing the risk or likelihood of developing, anastomotic leak or other microbe-mediated disorders by administering a therapeutically effective amount of a plasminogen inhibitor such as tranexamic acid and/or a phosphate-loaded polymer.
Claims8
A pharmaceutical composition comprising a plasminogen inhibitor and a phosphate-loaded triblock copolymer, wherein the triblock copolymer comprises:
- (a) a hydrophobic core;
- and
- (b) at least two polyethylene glycol chains,
- wherein
- at least one of the said two polyethylene glycol chains is a phosphorylated polyethylene glycol comprising more than two phosphate groups, and
- the dispersity (D) of the copolymer is less than or equal to 1.10.
Dependencies are inferred from the claim text.