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US 12,383,536 B2Granted
CRF receptor antagonists and methods of use
AssigneeNeurocrine Biosciences, Inc.
InventorsEvan Smith, Sha Luo, Gordon Raphael Loewen, Neil J. Ashweek, John P. Williams
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Abstract
Compounds are provided herein, as well as related preparations, compositions and methods for treating diseases and/or disorders that would benefit from the same such as congenital adrenal hyperplasia (CAH).
Claims4
A pharmaceutical composition comprising a compound of formula (IIa):
- or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient, wherein:
- each R2a is independently hydrogen or deuterium;
- R4a is
- R6a is C(RA)3;
- and
- each RA is independently hydrogen or deuterium.
3 more elements
A method of treating congenital adrenal hyperplasia in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a compound of formula (IIa):
- or a pharmaceutically acceptable salt thereof, wherein:
- each R2a is independently hydrogen or deuterium;
- R4a is
- R6a is C(RA)3;
- and
- each RA is independently hydrogen or deuterium.
3 more elements
Dependencies are inferred from the claim text.