Application of CaMK4 in preparation of medicine for preventing and treating psoriasis

Abstract

An application of CaMK4 as a target in preparation of medicines for preventing and treating psoriasis and an application of a CaMK4 inhibitor in preparation of medicines for preventing and treating psoriasis are provided. The expressions of CaMK4 in skin lesions of patients with psoriasis and IMQ induced skin lesions of mice with psoriasis are detected, and the results show that CaMK4 is positively correlated with psoriasis development. CaMK4 is expressed not only in immune cells, but also in keratinocytes. Moreover, IL-10 and the CaMK4 inhibitor can reduce psoriasiform inflammation induced by IMQ in mice. It shows that CaMK4 can be used as a new target in the preparation of medicines for prevention and treatment of psoriasis.

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