Disulfide-masked pro-chelator compositions and methods of use
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsElisa Tomat, Eman A. Akam
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Abstract
Pro-chelator compositions featuring disulfide masks that upon activation yield active chelators. The pro-chelator compositions may be activated intracellularly, for example within cells featuring metal ion dysregulation, cells that proliferate abnormally, etc. The pro-chelators of the present invention include thiosemicarbazones, semicarbazones, and aroyl hydrazones. The pro-chelator compositions of the present invention may be used for a variety of purposes including inhibiting cell proliferation, or treating conditions associated with metal ion dysregulation or abnormal cell proliferation.
Claims11
A metal pro-chelator comprising at least one pro-ligand and a disulfide bond, wherein the disulfide bond is connected to an aromatic ring of the pro-ligand at an ortho position, and wherein each pro-ligand comprises at least two donor atoms;
- wherein the metal pro-chelator excludes formulations according to:
A pro-chelator according to Formula III, wherein R is H, alkyl, aryl or a derivative thereof
Dependencies are inferred from the claim text.