Nanoliposome compositions and methods of using the same

A method of ameliorating one or more symptoms of medin-mediated cerebrovascular disease, the method comprising administering to a subject with the medin-mediated cerebrovascular disease, wherein the medin-mediated cerebrovascular disease is vascular dementia, stroke, Biswanger's disease, transient ischemic attack, cerebral infarction, or occlusion or stenosis of cerebral arteries, a composition comprising a nanoliposome and GM1 in an amount effective to ameliorate one more symptoms of medin-mediated cerebrovascular disease in the subject, wherein the nanoliposome comprises a phospholipid and cholesterol, wherein the phospholipid, the cholesterol, and the GM1 are present in a molar ratio of 70:25:5, respectively, thereby ameliorating one or more symptoms of the medin-mediated cerebrovascular disease.