Resident articles for gram-level dosing

An article for transesophageal administration to a subject, comprising:

• a plurality of discrete polymer matrices each comprising a polymeric material,
• each of the plurality of discrete polymer matrices having a hollow core;
• a therapeutic agent associated with each of the plurality of discrete polymer matrices;
• and
• a removable elastic wire disposed within the hollow cores thereby linking the plurality of discrete polymer matrices,
• wherein the plurality of discrete polymer matrices are encapsulated by a removable elastomeric overtube,
• wherein the article is configured to obtain a first, straightened configuration sized and adapted for transesophageal administration and/or retrieval to the subject when disposed within the removable elastomeric overtube,
• wherein, the article is configured to obtain a second, coiled configuration sized and adapted for gastric retention thereby preventing passage through the pylorus of the subject upon removal of the plurality of discrete polymer matrices from the removable elastomeric overtube,
• wherein change between the straightened configuration and the coiled configuration is mediated by the removable elastic wire, wherein the article undergoes elastic deformation when the plurality of discrete polymer matrices are removed from the removable elastomeric overtube,
• wherein the article has an uncoiled length of greater than or equal to 28 cm when in the first configuration, and
• wherein the therapeutic agent is present in the article in an amount greater than or equal to 3 grams.