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US 12,379,329 B2Granted
RF rapid diagnostics of infection and contamination
AssigneeNokomis, Inc.
InventorsWalter J Keller, III, James Robert Uplinger, II, Vladimir Makarenko
Life of this patent
Estimating the term…
Abstract
A rapid virus and pathogen detector using RF and Dielectric Spectroscopy. The targeted virus or pathogen is identified by active illumination by RF energy and analysis of the response RF signal.
Claims14
A method, comprising the steps of:
- a. receiving a sample in a sample holder, including receiving the sample holder in a measurement chamber comprising a tapered chamber with a tapered septum;
- b. illuminating the sample with a radio frequency (RF) radiation;
- c. receiving a response RF signal by from the sample;
- d. amplifying, with a low noise amplifier (LNA), the response RF signal;
- e. tuning the response RF signal;
- f. filtering the response RF signal;
- g. converting, with analog to digital converter (ADC), the response RF signal from an analog form to a digital form;
- h. transforming the response RF signal from a time domain to a frequency domain;
- i. breaking down, with a signal analysis unit connected to ADC, the response RF signal into components by sequentially applying a singular spectrum analysis (SSA);
- j. analyzing, with the signal analysis unit, selected components with unsupervised Density-Based Spatial Clustering of Applications with Noise (DBSCAN);
- and
- k. comparing, with the signal analysis unit, a digital spectrum signature of the response RF signal against a target virus spectrum signature or against a target pathogen spectrum signature.
9 more elements
A method, comprising the steps of:
- receiving a sample in a sample holder within a measurement chamber including a tapered chamber with a tapered septum;
- transmitting, with a transmitting antenna, a radio frequency (RF) radiation toward the sample;
- receiving, with a receiving antenna, a response RF signal from the sample;
- analyzing, with a signal analysis unit connected to the receiving antenna through a low noise amplifier (LNA), an RF receiver and analog to digital converter (ADC), the response RF signal;
- and
- comparing a spectrum signature of the response RF signal against a virus spectrum signature or against a pathogen spectrum signature.
3 more elements
A method, comprising the steps of:
- a. receiving a sample in a sample holder, including:
- exhaling a breath sample into a breath collection apparatus,
- pulling the breath sample through a pin aperture though one wall of a measurement chamber under a vacuum condition, the measurement chamber being in a fluid communication with the breath collection apparatus, and
- exhausting the sample with a vacuum through an aperture through another wall of the measurement chamber;
- b. illuminating the sample with a radio frequency (RF) radiation;
- c. receiving a response RF signal from the sample;
- d. amplifying, with a low noise amplifier (LNA), the response RF signal;
- e. tuning the response RF signal;
- f. filtering the response RF signal;
- g. converting, with analog to digital converter (ADC), the response RF signal from an analog form to a digital form;
- h. transforming the response RF signal from a time domain to a frequency domain;
- i. breaking down, with a signal analysis unit connected to ADC, the response RF signal into components by sequentially applying a singular spectrum analysis (SSA);
- j. analyzing, with the signal analysis unit, selected components with unsupervised Density-Based Spatial Clustering of Applications with Noise (DBSCAN);
- and
- k. comparing, with the signal analysis unit, a digital spectrum signature of the response RF signal against a target virus spectrum signature or against a target pathogen spectrum signature.
12 more elements
Dependencies are inferred from the claim text.