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US 12,379,239 B2Granted
Line volume calibration systems and methods
AssigneeLife Technologies Corporation
InventorGlen Davis
Life of this patent
Estimating the term…
Abstract
Provided are systems and methods for line volume calibration, and measurement of fluid samples delivered to an interrogation point. In various embodiments, a known fluid volume comprising a sample line fluid and a secondary fluid is delivered to a fluid boundary sensor. The fluid boundary sensor assists in determining the position of the boundaries between the various fluids, and the positions of these boundaries are used to determine the sample line fluid volume.
Claims19
A method for estimating a total volume of a sample fluid, comprising:
- communicating the total volume of fluid into a sample zone, the total volume of fluid comprising a volume of a sample fluid and a volume of a second fluid,
- communicating the total volume of fluid from the sample zone to a boundary sensor, the boundary sensor identifying a boundary between the sample fluid and the second fluid by detecting,
- a change in acoustic signal related to the boundary;
- and
- based on the boundary, determining the volume of the sample fluid in the total volume of fluid.
2 more elements
A system, comprising:
- a sample line;
- a sample zone;
- a pump configured to draw a total amount of fluid into the sample zone, the total amount of fluid comprising (1) a sample fluid that fills the sample line and (2) a second fluid;
- and
- a sensor region configured to receive the total amount of fluid from the sample zone,
- the sensor region comprising a sensor configured to identify a boundary between the sample fluid and the second fluid.
3 more elements
A system, comprising:
- a sample line,
- the sample line configured to contain a sample fluid;
- a sample zone,
- the sample zone configured to receive the sample fluid from the sample line and receive a second fluid such that the sample fluid and second fluid are comprised in a total amount of fluid;
- a sensor region,
- the sensor region comprising a sensor configured to identify a boundary between the sample fluid and the second fluid;
- and
- a flow diverter,
- the flow diverter being convertible between at least (i) a first state that places the sample line and sample zone into fluid communication with one another, (ii) a second state that places the sample zone and the sensor region into fluid communication with one another, and (iii) a third state that places the sample line into fluid communication with a source of sample fluid.
6 more elements
Dependencies are inferred from the claim text.