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US 12,378,611 B2Granted
Microbiome markers and uses thereof
AssigneeGnubiotics Sciences SA
InventorAdeyemi Adesokan
Life of this patent
Estimating the term…
Abstract
Bacterial species acting as biomarkers for obesity in domesticated cats and/or dogs are disclosed herein. Also disclosed are methods for diagnosing and/or treating cats and/or dogs having obesity or a predisposition to obesity as well as methods of screening for agents to treat or prevent obesity.
Claims10
A method of treating a domesticated cat for obesity or a predisposition to obesity comprising the steps of:
- a) measuring from a fecal sample obtained from the cat:
- i) a gut population of one or more bacterial species selected from Megasphaera elsdenii, Megamonas rupellensis, Megamonas funiformis, Megamonas hypermegale, and Bacteroides coprophilus;
- and
- ii) a gut population of one or more bacterial species selected from Lactobacillus reuteri and Blautia schinkii;
- b) determining that the domesticated cat is obese or has a predisposition for obesity when:
- i) the one or more bacterial species selected from Megasphaera elsdenii, Megamonas rupellensis, Megamonas funiformis, Megamonas hypermegale, and Bacteroides coprophilus is at a level below a pre-determined threshold for the selected bacterial species, or
- ii) the one or more bacterial species selected from Lactobacillus reuteri and Blautia schinkii is at a level above a pre-determined threshold for the selected bacterial species;
- and
- c) administering to the cat determined in b) to be obese or to have a predisposition to obesity:
- i) a therapeutically effective amount of a composition comprising an agent that selectively increases the gut population of Megasphaera elsdeni when the cat is determined to have a level of Megasphaera elsdeni below the pre-determined threshold for Megasphaera elsdeni;
- ii) a therapeutically effective amount of a composition comprising an agent that selectively increases the gut population of Megamonas rupellensis when the cat is determined to have a level of Megamonas rupellensis below the pre-determined threshold for Megamonas rupellensis;
- iii) a therapeutically effective amount of a composition comprising an agent that selectively increases the gut population of Megamonas funiformis when the cat is determined to have a level of Megamonas funiformis below the pre-determined threshold for Megamonas funiformis;
- iv) a therapeutically effective amount of a composition comprising an agent that selectively increases the gut population of Megamonas hypermegale when the cat is determined to have a level of Megamonas hypermegale below the pre-determined threshold for Megamonas hypermegale;
- or
- v) a therapeutically effective amount of a composition comprising an agent that selectively increases the gut population of Bacteroides coprophilus when the cat is determined to have a level of Bacteroides coprophilus below the pre-determined threshold for Bacteroides coprophilus;
- vi) a therapeutically effective amount of a composition comprising an agent that selectively decreases the gut population of Lactobacillus reuteri when the cat is determined to have a level of Lactobacillus reuteri above the pre-determined threshold for Lactobacillus reuteri;
- and/or
- vii) a therapeutically effective amount of a composition comprising an agent that selectively decreases the gut population of Blautia schinkii when the cat is determined to have a level of Blautia schinkii above the pre-determined threshold for Blautia schinkii.
15 more elements
A method of identifying and treating obesity or a predisposition to obesity in a domesticated cat comprising the steps of:
- a) receiving information obtained from the domesticated cat as to one or more of:
- i) a level of a gut population of one or more bacterial species selected from Megasphaera elsdenii, Megamonas rupellensis, Megamonas funiformis, Megamonas hypermegale, and Bacteroides coprophilus;
- and
- ii) a level of a gut population of one or more bacterial species selected from Lactobacillus reuteri and Blautia schinkii;
- and
- determining that the domesticated cat has obesity or a predisposition to obesity when the level in i) is below a predetermined threshold for the selected bacterial species, or when the level in ii) is above a predetermined threshold for the selected bacterial species;
- and
- b) treating the domesticated cat determined to be obese or to have a predisposition to obesity in a) by administering to the cat one or more of:
- i) a therapeutically effective amount of a composition comprising an agent that selectively increases the gut population of Megasphaera elsdeni when the cat is determined to have a level of Megasphaera elsdeni below the pre-determined threshold for Megasphaera elsdeni;
- ii) a therapeutically effective amount of a composition comprising an agent that selectively increases the gut population of Megamonas rupellensis when the cat is determined to have a level of Megamonas rupellensis below the pre-determined threshold for Megamonas rupellensis;
- iii) a therapeutically effective amount of a composition comprising an agent that selectively increases the gut population of Megamonas funiformis when the cat is determined to have a level of Megamonas funiformis below the pre-determined threshold for Megamonas funiformis;
- iv) a therapeutically effective amount of a composition comprising an agent that selectively increases the gut population of Megamonas hypermegale when the cat is determined to have a level of Megamonas hypermegale below the pre-determined threshold for Megamonas hypermegale;
- or
- v) a therapeutically effective amount of a composition comprising an agent that selectively increases the gut population of Bacteroides coprophilus when the cat is determined to have a level of Bacteroides coprophilus below the pre-determined threshold for Bacteroides coprophilus;
- vi) a therapeutically effective amount of a composition comprising an agent that selectively decreases the gut population of Lactobacillus reuteri when the cat is determined to have a level of Lactobacillus reuteri above the pre-determined threshold for Lactobacillus reuteri;
- and/or
- vii) a therapeutically effective amount of a composition comprising an agent that selectively decreases the gut population of Blautia schinkii when the cat is determined to have a level of Blautia schinkii above the pre-determined threshold for Blautia schinkii.
14 more elements
Dependencies are inferred from the claim text.