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US 12,378,586 B2Granted
Systems, methods, and compositions for the glycosylation of cannabinoid compounds
AssigneeTrait Biosciences, Inc.
InventorsTimothy Travers, Erick LeBrun
Life of this patent
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Abstract
The present invention relates generally to the identification novel UDP-glucosyltransferases enzymes having specific activity towards cannabinoid compounds. The present invention further relates generally to the use of novel UGT enzymes having specific activity towards cannabinoid compounds to generate water-soluble cannabinoid glycoside compounds.
Claims4
A system for producing glycosylated cannabidiol (CBD) comprising:
- a yeast cell culture, where the yeast cells express a heterologous nucleotide sequence, operably linked to a promoter, encoding a UDP-glucosyltransferases (UGT) according to the amino acid sequence SEQ ID NO. 1, or a sequence having at least 95% sequence identity with SEQ ID NO. 1826;
- and
- wherein CBD is introduced to the culture where the UGT glycosylates said CBD generating a CBD glycoside.
A system for producing glycosylated tetrahydrocannabinol (THC) comprising:
- a yeast cell culture, where the yeast cells express a heterologous nucleotide sequence, operably linked to a promoter, encoding a UDP-glucosyltransferases (UGT) according to the amino acid sequence SEQ ID NO. 1, or a sequence having at least 95% sequence identity with SEQ ID NO. 1826;
- and
- wherein THC is introduced to the culture where the UGT glycosylates said THC generating a CBD glycoside.
Dependencies are inferred from the claim text.