Sequence multiplicity within spherical nucleic acids
AssigneeNorthwestern University
InventorsChad A. Mirkin, Ziyin Huang
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Abstract
The present disclosure is directed to spherical nucleic acids (SNAs) comprising a nanoparticle core and an oligonucleotide shell attached to the external surface of the nanoparticle core, wherein the oligonucleotide shell comprises a mixture of class A CpG oligonucleotides and class B CpG oligonucleotides. The disclosure also provides methods of using the SNAs for, e.g., regulation of an immune response and gene regulation.
Claims23
A spherical nucleic acid (SNA) comprising a nanoparticle core and an oligonucleotide shell attached to the external surface of the nanoparticle core, wherein the oligonucleotide shell comprises a mixture of class A CpG oligonucleotides and class B CpG oligonucleotides, wherein the ratio of class A CpG oligonucleotides to class B CpG oligonucleotides in the mixture is about 7:3 and wherein the SNA does not comprise a class C CpG oligonucleotide.
Dependencies are inferred from the claim text.