Oligomeric compound for inhibiting expression of factor XI
AssigneeSirnaomics, Inc.
InventorDmitry Samarsky
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Abstract
Products, compositions, and their uses are provided. In particular, nucleic acid products that modulate, in particular interfere with or inhibit, Factor XI (FXI) gene expression are provided. The products can be oligomeric compounds that comprise at least a first region of linked nucleosides having at least a first nucleobase sequence that is at least partially complementary to at least a portion of RNA transcribed from an FXI gene, wherein said first nucleobase sequence is selected from the following sequences, or a portion thereof: SEQ ID NOs 1 to 250.
Claims20
An oligomeric compound that inhibits expression of Factor XI (“FXI”), comprising a single oligonucleotide strand, wherein said single strand consists of a modified or unmodified oligonucleotide selected from the group consisting of SEQ ID NOs:
- 2252, 2287, 2288, 2290-2292, 2297, 2300, 2303, 2306, 2309, 2312, 2315, 2321, 2324, 2327, 2332, 2334-2336, 2338, 2339, 2343, 2348, 2351, 2352, 2354, 2355, and 2357-2366.
Dependencies are inferred from the claim text.