Chimeric protein toxins for expression by therapeutic bacteria
AssigneeDavid Bermudes
InventorsDavid Gordon Bermudes, David Quintero
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Abstract
Bacteria with tumor-targeting capability express, surface displayed, secreted and/or released modified chimeric therapeutic proteins with enhanced therapeutic activity against a neoplastic tissue including solid tumors, lymphomas and leukemias. The bacteria may be attenuated, non-pathogenic, low pathogenic or a probiotic. The chimeric proteins may be protease sensitive and may optionally be further accompanied by co-expression of a secreted protease inhibitor as a separate molecule or as a fusion.
Claims15
A chimeric protease inhibitor comprising:
- a bacterial secretion signal peptide comprising YebF;
- and
- a serine protease inhibitor peptide comprising sunflower trypsin inhibitor;
- wherein the bacterial secretion signal peptide and the serine protease inhibitor peptide are fused to form a chimeric peptide.
A chimeric protease inhibitor comprising a bacterial secretion signal comprising YebF, linked through at least one amino acid to a serine protease inhibitor peptide sequence comprising sunflower trypsin inhibitor.
Dependencies are inferred from the claim text.