Biohybrid peptidoglycan oligomers
AssigneesNanyang Technological University, National University of Singapore
InventorsXuewei Liu, Bee Eng Mary Chan, Hongwei Duan, Jingxi He, Kim Le Mai Hoang, Liang Yang
Life of this patent
Estimating the term…
Abstract
The invention relates to a compound of formula Ia and/or formula Ib: or a pharmaceutically acceptable salt, solvate or prodrug thereof, where the groups are defined herein. The invention also relates to a pharmaceutical formulation comprising the compound for treating or detecting a microbial infection in a subject, a method of determining antimicrobial resistance of a microbial infection using the compound, and a method of determining an effective dose of one or more antimicrobial agents to kill a microorganism using the compound.
Claims20
A compound of formula Ia and/or formula Ib:
- wherein:
- R1 represents C1 to C20 alkyl or —CH2CH(CO2H)OC1-20 alkyl;
- R2 and R3 each independently represent —C(═O)R7;
- R4 to R6 each represent H;
- each R7 independently represents C1 to C20 alkyl;
- X1 and X2 independently represent -AA1-AA2-AA3-D-Ala-AA4, where:
- AA1 is selected from L-Ala, L-Gly, D-Gly or L-Ser;
- AA2 is selected from D-isoglutamate (γ-D-glutamate, γ-D-Glu), D-isoglutamine, or threo-3-hydroxyglutamate;
- AA3 is selected from L-homoserine, D-homoserine, D-5-hydroxylysine, D-Orn, L-Lys, D-Lys, L-Orn, L-2,4-diaminobutyrate, or L-5-hydroxylysine, where the amino group is functionalised to become a NHR8 group and/or, where present, the hydroxyl group is functionalised to become a OR8 group;
- and
- AA4 is selected from D-Ala, D-Ser or D-Lacate (D-Lac),
- at each occurrence R8 is independently selected from one or more of H, a fluorescent group or a pharmaceutically active moiety,
- n and m, and n′ and m′ are alternating repeating units, where n is from 5 to 100 and m is from 4 to 100, provided that m has the same value as n or is n−1 and n′ is from 5 to 100 and m′ is from 4 to 100, provided that m′ has the same value as n′ or is n′−1,
- p or p′ are 1 or 0, or
- a pharmaceutically acceptable salt, solvate or prodrug thereof.
Dependencies are inferred from the claim text.