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US 12,378,324 B2Granted
Anti superoxide dismutase 1 (SOD1) antibodies and use thereof
AssigneeB. G. Negev Technologies and Applications Ltd., At Ben-Gurion University
InventorsStanislav Engel, Zeev Barak
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Abstract
The present invention is directed to an antibody or an antigen-binding portion thereof having specific binding affinity to a misfolded SOD1. Pharmaceutical compositions comprising same and methods of using same are also provided.
Claims17
An antibody or an antigen-binding portion thereof, the antibody comprising three heavy chain CDRs (CDR-H) and three light chain CDRs (CDR-L), wherein:
- CDR-H1 comprises the amino acid sequence set forth in SEQ ID NO:
- 1 (DSAIH), CDR-H2 comprises the amino acid sequence as set forth in SEQ ID NO:
- 2 (WINTYTGKPTYADDFKG), CDR-H3 comprises the amino acid sequence as set forth in SEQ ID NO:
- 3 (SVYSYDGTFYRYFLDA), CDR-L1 comprises the amino acid sequence as set forth in SEQ ID NO:
- 4 (RASESVSKHIH), CDR-L2 comprises the amino acid sequence as set forth in SEQ ID NO:
- 5 (LASSLES), and CDR-L3 comprises the amino acid sequence as set forth in SEQ ID NO:
- 6 (QQSWNDPWT).
4 more elements
Dependencies are inferred from the claim text.