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US 12,378,284 B2Granted
Compositions and methods for the delivery of nucleic acids
AssigneeCase Western Reserve University
InventorsZheng-Rong Lu, Amita M. Vaidya
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Abstract
A nanosized complex includes siRNA and a compound comprising formula (I):
Claims16
A nanosized complex comprising siRNA and a compound comprising formula (I):
- wherein R1 is an alkylamino group or a group containing at least one aromatic group;
- R2 and R3 are independently an aliphatic group or a hydrophobic group;
- R4 and R5 are independently H, a substituted or unsubstituted alkyl group, an alkenyl group, an acyl group, an aromatic group, polymer, a targeting group, or a detectable moiety;
- a, b, c, and d are independently an integer from 1 to 10;
- and
- pharmaceutically acceptable salts thereof,
- wherein the siRNA inhibits expression of an oncogenic nucleic acid upon delivery of the nanosized complex to a cell.
4 more elements
A method of treating cancer in a subject in need thereof, the method comprising:
- administering to the subject a nanosized complex comprising siRNA and a compound comprising formula (I):
- wherein R1 is CH2CH2NH2;
- R2 and R3 are independently an aliphatic group or a hydrophobic group;
- R4 and R5 are independently H, a substituted or unsubstituted alkyl group, an alkenyl group, an acyl group, an aromatic group, polymer, a targeting group, or a detectable moiety;
- a, b, c, and d are independently an integer from 1 to 10;
- and pharmaceutically acceptable salts thereof,
- wherein the siRNA inhibits expression of an oncogenic nucleic acid upon delivery of the nanosized complex to a cancer cell.
4 more elements
Dependencies are inferred from the claim text.