Porous inorganic carrier and method for producing nucleic acid using same

An inorganic porous carrier, comprising:

• a linker of formula (2);
• and
• an inorganic porous substance connected to the linker,
• wherein the inorganic porous substance has a mode diameter in a pore distribution as measured by mercury intrusion method from 0.04 μm to 1 μm, and
• the inorganic porous substance has a cumulative pore volume ratio of 30% or less, where the cumulative pore volume ratio is a ratio of cumulative pore volume VB whose pore size is within a range of 0.004 μm to 0.04 μm to cumulative pore volume VA whose pore size is within a range of 0.04 μm to 1 μm,
• wherein,
• a bond marked with * is a linkage to an oxygen atom of a silanol group in the inorganic porous substance;
• n is an integer of 1, 2 or 3;
• R is independently of each other an alkyl group including 3 to 10 carbon atoms which may optionally have a substituent selected from the group consisting of an alkoxy group and a fluorine atom;
• a phenyl group which may optionally have a substituent selected from the group consisting of an alkyl group, an alkoxy group, and a fluorine atom;
• a hydroxyl group;
• or an alkoxy group including 1 to 4 carbon atom;
• L is a single bond;
• an alkylene group including 1 to 20 carbon atoms;
• or an alkylene group including 2 to 20 carbon atoms which includes —CH2-Q-CH2— group wherein Q is selected from the group consisting of —O—, —NH—, —NH—CO—, and —NH—CO—NH—, Q is inserted into at least one —CH2-CH2— group constituting the alkylene group, and a carbon atom of a methylene group bonded to Q is not bonded to another group Q;
• Rb is a nucleoside or a nucleotide;
• and
• L1 is a divalent group bonded to an oxygen atom of a primary or a secondary hydroxy group of Rb.