US 12,378,260 B2 · Benzotriazole compound

Benzotriazole compound

AssigneesDaiichi Sankyo Company, Limited, Kyoto Pharmaceutical Industries, Ltd.

InventorsYoshihiro Ogura, Rieko Takano, Junya Kawai, Teppei Fujimoto, Masaharu Inui, Masafumi Ofuku, Masaki Miyazaki, Masaya Fujii, Ken Ishii, Wakana Yokozeki, Kazuya Otake, Shunsuke Takashima, Masafumi Ando

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Abstract

The present invention aims to provide a medicament capable of treating and/or preventing diseases associated with oxidative stress by inhibiting the protein-protein interaction between Keap1 and Nrf2 and activating Nrf2. The present invention relates to a compound represented by the following formula (1): wherein each symbol is as described in the DESCRIPTION, or a pharmaceutically acceptable salt thereof. In addition, the present invention also relates to a medicament containing the aforementioned compound, for the prophylaxis and/or treatment of diseases involving oxidative stress selected from the group consisting of chronic kidney disease, non-alcoholic steatohepatitis, chronic obstructive pulmonary disease, radiation skin disorder, radiation mucosal disorder, cardiac failure, pulmonary arterial hypertension, Parkinson's disease, Friedreich's ataxia, multiple sclerosis, age-related macular degeneration, retinitis pigmentosa and glaucoma.

Claims8

Dependent claims

A compound represented by the following formula (1′):

wherein
R1a′ and R1b′ are each independently a hydrogen atom or a methyl group,
R2′ is a methyl group,
R3′ is a chlorine atom or a methyl group,
Y′ is —CH—, —CR4′— or a nitrogen atom,
R4′ is a chlorine atom, a methyl group, a cyclopropyl group, a difluoromethoxy group or a trifluoromethoxy group,
—V′— is a group represented by any of the following formulas:
wherein *′ and **′ are each a bonding position to a benzene ring,
R5a′ and R5b′ are each independently a hydrogen atom or an ethyl group, or R5a′ and R5b′ are bonded together to form cyclopropane,
R6′ in the number of m′ are each independently a fluorine atom or a chlorine atom,
m′ is an integer of 0 to 2, and
W′ is an oxygen atom,
or a pharmaceutically acceptable salt thereof.

10 more elements

Dependencies are inferred from the claim text.

Facts

Application

18/927,756Filed 25 Oct 2024 · continuation

Priority

JP 2022-07522328 Apr 2022

Published

US 2025/0092064 A120 Mar 2025

Granted

5 Aug 2025

Term ends

Not estimatedThe source records don’t support an estimate.

Classification41 codes

A61P 1/16
Drugs for disorders of the alimentary tract or the digestive system: for liver or gallbladder disorders, e.g. hepatoprotective agents,…
C07D 515/04
In which the condensed system contains two hetero rings: ortho-condensed systems
A61K 31/4192
Having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole: 1,2,3-Triazoles
A61K 31/554
Having seven-membered rings, e.g. azelastine, pentylenetetrazole: having at least one nitrogen and one sulfur as ring hetero atoms, e.g.…