Biologically active molecules, conjugates thereof, and therapeutic uses
AssigneeRegeneron Pharmaceuticals, Inc.
InventorThomas Nittoli
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Abstract
The present disclosure relates to linker compounds that are useful in covalently linking biologically active molecules with Ligands. The disclosed compounds also relate to biologically active molecules and Ligand conjugates, wherein the biologically active molecule is linked to the Ligand through a linker. The disclosure further provides compositions comprising biologically active molecule-ligand conjugates, methods of modifying abnormal cell growth and methods of treatment using the conjugates or the compositions.
Claims12
A method for reducing, retarding, or stopping an abnormal cell growth comprising contacting one or more cells growing abnormally with a compound, in an amount sufficient to retard, reduce, or stop the abnormal cell growth, and wherein the compound has the following formula
- wherein A3a is —CH2—, —CH2CH2—, or —CH2CH2CH2CH2—;
- and
- R4a is a substituted or unsubstituted alkyl, alkenyl, alkynyl, aryl, heteroaryl, or heterocyclyl.
Dependencies are inferred from the claim text.