Carbonic anhydrase inhibitors and antibiotics against multidrug resistant bacteria
AssigneePurdue Research Foundation
InventorsDaniel P Flaherty, Mohamed Seleem, Jatinder Kaur, Xufeng Cao
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Abstract
The invention described herein generally relates to novel therapeutic compounds, and in particular to carbonic anhydrase inhibitors as a narrow spectrum antibiotics against drug resistant bacteria and methods for treating those infection diseases in mammals using the described carbonic anhydrase inhibitors or a pharmaceutical formulation thereof.
Claims12
A method for treating a patient with a bacterial infection comprising the step of administrating a therapeutically effective amount of a carbonic anhydrase inhibitor having the formula (I), or a pharmaceutically acceptable salt thereof, together with one or more diluents, excipients or carriers, to the patient in need of treatment for said infection,
- wherein
- R1 is
- or
- an alkynyl, each of which is optionally substituted.
A method for decolonizing a patient with a bacterial infection comprising the step of administrating a therapeutically effective amount of a carbonic anhydrase inhibitor having the formula (I), or a pharmaceutically acceptable salt thereof, together with one or more diluents, excipients or carriers, to the patient in need of treatment,
- wherein
- R1 is
- or
- an alkynyl, each of which is optionally substituted.
A compound having the formula (I)
- or a pharmaceutically acceptable salt thereof, wherein
- R1 is
- or
- an alkynyl, each of which is optionally substituted.
Dependencies are inferred from the claim text.