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US 12,378,210 B2Granted
Pharmaceutical composition comprising tizoxanide and pharmaceutical use thereof
AssigneeBeijing Junke Huayuan Med Tech Co., Ltd.
InventorsBohua Zhong, Ming Zhou, Hongwu Li
Life of this patent
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Abstract
A pharmaceutical composition contains tizoxanide and choline hydroxide, a choline salt of tizoxanide and crystal form thereof. A mixture of tizoxanide and choline hydroxide, or a salt thereof and crystal form of the salt significantly improve the solubility and bioavailability of tizoxanide, and exhibits favorable effects in drugs for treating viruses, fibrosis, bacteria, tumors and intestinal parasites.
Claims15
A pharmaceutical composition, containing tizoxanide and choline hydroxide.
A tizoxanide choline salt of formula (I),
A crystalline form of a tizoxanide choline salt of formula (I),
- wherein the crystalline form has characteristic peaks at the following 2θ angles (°) in a powder X-ray diffraction pattern obtained using Cu-Kα radiation:
- 9.92±0.10, 15.10±0.10, 16.16±0.10, 19.72±0.10, 19.88±0.10, 20.69±0.10, 25.66±0.10 and 27.59±0.10, wherein the peak at 9.92±0.10 is the strongest peak.
Dependencies are inferred from the claim text.