Triazole compounds and preparation method therefor and use thereof
AssigneeWuhan Ll Science and Technology Development Co., Ltd.
InventorsJun Lou, Yongkai Chen, Wei Peng, Yihan Zhang, Xiaodan Guo, Li Liu, Junhua Liu, Lina Qian, Chaodong Wang
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Abstract
Certain triazole compounds have good LPAR1 antagonistic activity and selectivity, low toxicity, and good metabolic stability, and can be used for preventing or treating the LPAR1-related disease or disorder. The IC50 value of some triazole compounds can be below 300 nM, even 50 nM. The range of CC50 of the triazole compounds can be greater than 200 μM. They also show good metabolic stability in human, fancy rats, and house mice.
Claims8
A triazole compound of formula (I) or a stereoisomer, a tautomer, an isotopically labeled compound, a nitrogen oxide, a solvate, a polymorph, an ester, or a pharmaceutically acceptable salt thereof,
- wherein,
- R1 is selected from H and CH3;
- R2 is selected from the following groups:
- R3 is selected from H and the following groups:
- or, R1 is CH3, R2 is selected from the following groups:
A triazole compound or a stereoisomer, a tautomer, an isotopically labeled compound, a nitrogen oxide, a solvate, a polymorph, a ester, or a pharmaceutically acceptable salt thereof,
- wherein the triazole compound is selected from
Dependencies are inferred from the claim text.