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US 12,378,178 B2Granted
Oleic acid derivatives as treatments for Friedreich ataxia and inhibitors of ferroptosis
AssigneesThe Trustees of the University of Pennsylvania, The Children's Hospital of Philadelphia
InventorsAmos Smith, Robert B. Wilson, Donna M Huryn, Maria Grazia Cotticelli, Shujuan Xia, Taehee Lee, Roberto Forestieri
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Abstract
The invention relates to compounds of Formula I or Formula II: to compositions comprising such compounds, and to methods of use thereof for treating neurodegenerative disorders, such as Friedreich ataxia.
Claims16
A compound represented by Formula I
- wherein
- R is H or C1-C6 alkyl;
- m is an integer from 3 to 8;
- n is an integer from 3 to 8;
- and
- Y is CF3 or CCl3,
- or an optical isomer thereof.
4 more elements
A method of treating Friedreich ataxia in a subject, comprising administering to the subject an effective amount of a compound having the following formula:
- or a pharmaceutical composition thereof.
Dependencies are inferred from the claim text.