Automated method and apparatus for preparing bioprocess solutions

An automated bioprocess solution preparation apparatus comprising:

• a first mixing chamber configured to contain at least one ingredient for a bioprocess solution, the first mixing chamber comprising a first port and a second port for a fluid to enter the mixing chamber and a third port for a liquid bioprocess solution prepared from the ingredients to exit the mixing chamber;
• an array of tubing for fluid flow within the apparatus;
• a sensor arranged to measure a property of the liquid bioprocess solution exiting the mixing chamber;
• a first valve associated with the first port;
• a second valve associated with the second port;
• a third valve associated with the third port;
• and
• a control system programmed to pulse an internal pressure of the first mixing chamber by closing and opening the third valve,
• wherein, when the property meets or exceeds a threshold value, the apparatus is operable to perform at least one of the steps of:
• closing the first valve to block the fluid from entering the mixing chamber through the first port, and
• opening the second valve for the fluid to enter the mixing chamber through the second port.

An automated bioprocess solution preparation apparatus comprising:

• a first mixing chamber configured to contain at least one ingredient for a bioprocess solution, the first mixing chamber comprising a first port and a second port for a fluid to enter the mixing chamber and a third port for a liquid bioprocess solution prepared from the ingredients to exit the mixing chamber;
• an array of tubing for fluid flow within the apparatus;
• a sensor arranged to measure a property of the liquid bioprocess solution exiting the mixing chamber;
• a first valve associated with the first port;
• a second valve associated with the second port;
• and
• a computing system configured to control the mixing apparatus, wherein the computing system is programmed to, in response to the property meeting or exceeding a threshold value:
• fully close the first valve to block the fluid from entering the mixing chamber through the first port;
• and
• open the second valve from a fully closed position for the fluid to enter the mixing chamber through the second port.