Receptacle for pharmaceutical packaging having a graduated lubricant layer

A kit, comprising:

• a receptacle, the receptacle comprising:
• an elongate barrel section, the elongate barrel section having a direction of elongate extension and an axis in the direction of elongate extension, an axial position p is determined along the axis, the elongate barrel section extends from an axial position pA to an axial position pB, wherein pA is a first axial terminal end position of the elongate barrel section and pB is a second axial terminal end position of the elongate barrel section that is opposite the first axial terminal end position and an elongate barrel section length LB is a distance between pA and pB;
• a side wall extending over the elongate barrel section, the side wall having an inner surface bordering an interior, the interior having a diameter;
• and
• a layer of a lubricant located on at least a part of the inner surface;
• at a given axial position p on the axis between pA and pB, a thickness of the side wall, a thickness of the layer, and the diameter of the interior are each determined as an angular mean in a cross-sectional plane perpendicular to the axis at the axial position p;
• a portion X of the axis extends from an axial position p1 to an axial position p2 such that the following criteria are satisfied:
• both p1 and p2 lie between pA and pB,
• a portion length LX is a distance between p1 and p2,
• LX is at least 60% of the length LB,
• the layer extends over the entire portion X, and
• a thickness t1 of the layer at p1 is less than a thickness t2 of the layer at p2, wherein the thickness of the layer increases monotonically over the entire portion X from p1 to p2;
• wherein at least one criteria is satisfied and is selected from the group consisting of:
• the length LB is in a range from 3 cm to 20 cm;
• a mean value of the diameter of the interior determined over a range pA to pB is in a range from 0.4 cm to 4 cm;
• a mean thickness of the sidewall determined over the range pA to pB is in a range from 0.3 mm to 4 mm;
• and
• a volume of the interior is in a range from 0.1 ml to 150 ml;
• and
• a charge that is adapted and arranged to be positioned in the interior such that:
• i. the charge seals a cross section of the interior between the inner surface of the side wall and another inner surface of a second side wall;
• ii. the charge has a front end at an axial position closest to pB at which the charge contacts the layer or the inner surface;
• iii the charge has a back end at an axial position closest to pA at which the charge contacts the layer or the inner surface;
• iv a length of the charge LC is a distance between the front end and the back end;
• v. the charge has a charge axial position, being the axial position of the front end;
• and
• vi. the charge is movable in a direction parallel to the axis with a stiction s, the stiction s being a function of the charge axial position.

An assembly, comprising:

• a receptacle, the receptacle comprising:
• an elongate barrel section, the elongate barrel section having a direction of elongate extension and an axis in the direction of elongate extension, an axial position p is determined along the axis, the elongate barrel section extends from an axial position pA to an axial position pB, wherein pA is a first axial terminal end position of the elongate barrel section and pB is a second axial terminal end position of the elongate barrel section that is opposite the first axial terminal end position and an elongate barrel section length LB is a distance between pA and pB;
• a side wall extending over the elongate barrel section, the side wall having an inner surface bordering an interior, the interior having a diameter;
• and
• a layer of a lubricant located on at least a part of the inner surface;
• at a given axial position p on the axis between pA and pB, a thickness of the side wall, a thickness of the layer, and the diameter of the interior are each determined as an angular mean in a cross-sectional plane perpendicular to the axis at the axial position p;
• a portion X of the axis extends from an axial position p1 to an axial position p2 such that the following criteria are satisfied:
• both p1 and p2 lie between pA and pB,
• a portion length LX is a distance between p1 and p2,
• LX is at least 60% of the length LB,
• the layer extends over the entire portion X, and
• a thickness t1 of the layer at p1 is less than a thickness t2 of the layer at p2, wherein the thickness of the layer increases monotonically over the entire portion X from p1 to p2;
• wherein at least one criteria is satisfied and is selected from the group consisting of:
• the length LB is in a range from 3 cm to 20 cm;
• a mean value of the diameter of the interior determined over a range pA to pB is in a range from 0.4 cm to 4 cm;
• a mean thickness of the sidewall determined over the range pA to pB is in a range from 0.3 mm to 4 mm;
• and
• a charge, wherein:
• a. the receptacle has an aperture;
• b. the charge is positioned in the interior sealing a cross section of the interior;
• c. the interior contains a liquid pharmaceutical composition, located between the sealed cross section and the aperture;
• and
• d. the assembly is adapted and arranged for the liquid pharmaceutical composition to be ejected through the aperture by movement of the charge in a direction parallel to the axis.