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US 12,377,189 B2Granted
Osteoinductive bone implant including harvested demineralized bone and bone morphogenetic proteins bound thereto obtained from the same donor
AssigneeBioventus, LLC
InventorAmit Prakash Govil
Life of this patent
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Abstract
Disclosed are various bioactive grafts and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized.
Claims5
A bone implant comprising:
- demineralized bone harvested from a donor;
- and
- bone morphogenetic proteins obtained by release and solubilization from one or more of cellular material, bone marrow, and blood, each from the same donor as the harvested bone;
- wherein the bone morphogenetic proteins are bound to the demineralized bone after release and solubilization.
1 more element
Dependencies are inferred from the claim text.