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AssigneeZhejiang University
InventorsZhengwei Mao, Lisha Yu, Weilin Wang, Yuan Ding
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The present invention provides a double-crosslinked fibrin gel, which is a solid hydrogel composed of a network structure with a blocking function and a network structure with an adhesion function, where the network structure with the blocking function is a three-dimensional fibrin network, and the network structure with the adhesion function is a three-dimensional photosensitive gel network; each channel of the photosensitive gel network has a group of the fibrin network inside, and each group of the fibrin network has overall continuity; on the whole, the three-dimensional fibrin network disperses disorderly throughout a surface and an interior of the solid hydrogel. The present invention further provides a raw material composition, a kit for preparing the double-crosslinked fibrin gel, and an application of the kit to prepare an in-situ rapid clotting and hemostatic material. The double-crosslinked fibrin gel prepared by the kit has a fast and efficient hemostatic effect, also can be widely applied for hemostasis of accidental trauma or a surgical wound.
A raw material composition for preparing a double-crosslinked fibrin adhesive for rapid hemostasis in a bleeding wound in situ by mixing, comprising:
Dependencies are inferred from the claim text.