Magnetic nanoparticles functionalized with N-(3,4-dihydroxyphenethyl)dodecanamide, production and use thereof
AssigneeColorobbia Italia S.P.A.
InventorsGiovanni Baldi, Costanza Ravagli, Mauro Comes Franchini, Mario Milco D'Elios, Marisa Benagiano, Marco Bitossi
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Abstract
There are described magnetic nanoparticles the surface of which is functionalized with catechol and constructs comprising a plurality of said nanoparticles encapsulated in a biocompatible polymer matrix, wherein a molecule with therapeutic action is optionally dispersed, said polymer matrix optionally being in turn further functionalized; there are further described cells of the immune system incorporating said polymeric constructs giving rise to their engineering.
Claims8
A construct comprising a plurality of magnetic nanoparticles consisting of nanometric magnetite particles whose surface is functionalized with N-(3,4-dihydroxyphenethyl) dodecanamide, said nanometric magnetite particles with surface functionalized with N-(3,4-dihydroxyphenethyl) dodecanamide are arranged in an assembly in which each of said nanometric magnetite particles with surface functionalized with N-(3,4-dihydroxyphenethyl) dodecanamide is in contact with at least one other of said nanometric magnetite particles with surface functionalized with N-(3,4-dihydroxyphenethyl)dodecanamide, said assembly encapsulated in a biocompatible polymeric matrix wherein a molecule having therapeutic action is optionally dispersed.
Dependencies are inferred from the claim text.