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US 12,377,159 B2Granted
Steroids and protein-conjugates thereof
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsAmy Han, Andrew J. Murphy, William Olson
Life of this patent
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Abstract
Described herein are protein steroid conjugates that are useful, for example, for the target-specific delivery of glucocorticoids (GCs) to cells.
Claims23
A compound of Formula (A):
- or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, wherein:
- R1 and R2 together form
- wherein R4 is linear or branched alkyl, aryl, arylalkyl, or an N-containing heterocycloalkyl,
- wherein the alkyl, aryl, arylalkyl, and N-containing heterocycloalkyl are, independently in each instance, optionally substituted with —NRcRd,
- wherein Rc and Rd are, independently in each instance, —H, alkyl, or optionally substituted aryl;
- R3 is —NRaRb,
- wherein Ra and Rb are, independently in each instance, —H, alkyl, or optionally substituted aryl;
- R5 is, independently in each instance, —OH, halo, alkyl, or arylalkyl;
- and
- n is an integer from 0-19.
7 more elements
Dependencies are inferred from the claim text.