Composition, comprising thiamine derivative, for prevention or treatment of hypercortisolemia
AssigneeKyungpook National University Industry-Academic Cooperation Foundation
InventorsIn Kyu Lee, Jae Han Jeon, Hyeon-Ji Kang
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Abstract
The present invention relates to a composition for prevention or treatment of hypercortisolemia, the composition comprising allithiamine, fursultiamine, and benfotiamine, which are all derivatives of thiamine, or a mixed composition thereof. The composition for prevention or treatment of hypercortisolemia of the present invention can effectively treat or alleviate symptoms or disorders resulting from excessive secretion of cortisol, without surgical operations, and does not exhibit side effects caused by conventional medications.
Claims3
A method for treating hypercortisolism in a subject, the method comprising the steps of:
- identifying a subject in need of treatment for hypercortisolism;
- and
- administering to the subject a pharmaceutical composition consisting of (i) fursultiamine or a pharmaceutically acceptable salt thereof, and (ii) optionally a pharmaceutically acceptable carrier,
- wherein the fursultiamine directly inhibits cortisol synthesis in adrenocortical cells, thereby treating hypercortisolism in the subject.
A method for treating cortisol-induced hypertension, cortisol-induced diabetes, cortisol-induced obesity or cortisol-induced depression in a subject, the method comprising the steps of:
- identifying a subject in need of treatment for cortisol-induced hypertension, cortisol-induced diabetes, cortisol-induced obesity or cortisol-induced depression;
- and
- administering to the subject a pharmaceutical composition consisting of (i) fursultiamine or a pharmaceutically acceptable salt thereof, and (ii) optionally a pharmaceutically acceptable carrier,
- wherein the fursultiamine directly inhibits cortisol synthesis in adrenocortical cells, thereby treating cortisol-induced hypertension, cortisol-induced diabetes, cortisol-induced obesity, or cortisol-induced depression in the subject.
Dependencies are inferred from the claim text.