Back to results
US 12,377,055 B2Granted
Dissolvable gel-forming film for delivery of active agents
AssigneeSmith & Nephew, Inc.
InventorsLei Shi, Aleksa Jovanovic, Dennis Carson
Life of this patent
Estimating the term…
Abstract
Disclosed is a dissolvable, gel-forming film, and methods for its use, comprising a water-soluble cellulose ether, a hydrophilic rheological modifying agent, and an active proteolytic enzyme or other drug substance. The gel-forming film has a water content of less than 15% w/w and is capable of forming a hydrogel when contacted with water or other aqueous medium. The disclosed films achieve delivery of stable proteolytic enzymes to the desired site of action in a manner that provides uniform delivery of the enzymes.
Claims20
A method of applying a dissolvable, gel-forming film to a surface,
- wherein the dissolvable, gel-forming film comprises a water-soluble cellulose ether, a hydrophilic rheological modifying agent, and a protease,
- wherein the dissolvable, gel-forming film has a water content of less than 15% w/w, and
- wherein the dissolvable, gel-forming film is capable of forming a hydrogel when 1 gm of gel-forming film is contacted with 20 ml of water or other aqueous medium.
Dependencies are inferred from the claim text.