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AssigneeCernostics, Inc.
InventorsRebecca Jane Thorne, Bruce B. Campbell
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The invention provides a system, composition, and methods of using the systems and compositions for the analysis of a sample from a subject to accurately diagnose, prognose, or classify the subject with certain grades of or susceptibility to Barrett's esophagus. In some embodiments, the system of the present invention comprises a means of detecting and/or quantifying morphological features, the expression of protein, or the expression of nucleic acids in a plurality of cells and correlating that data with a subject's medical history to predict clinical outcome, treatment plans, preventive medicine plans, or effective therapies. In some embodiments, the invention relates to a method of classifying and compiling data taken from a cell sample from a subject analyzing the data, and converting the data from the system into a score by which a pathologist may calculate the likelihood that the subject develops cancer.
A method of treating Barrett's esophagus in a subject with low grade dysplasia, high grade dysplasia, or esophageal adenocarcinoma wherein the method comprises classifying an upper gastrointestinal sample of the subject as having low grade dysplasia, high grade dysplasia, or esophageal adenocarcinoma with a kit comprising:
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