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US 12,372,515 B2Granted
Engineered tissues for in vitro research uses, arrays thereof, and methods of making the same
AssigneeOrganovo, Inc.
InventorsKeith Murphy, Chirag Khatiwala, Scott Dorfman, Benjamin Shepherd, Sharon Presnell, Justin Robbins
Life of this patent
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Abstract
Disclosed are living, three-dimensional tissue constructs for in vitro scientific and medical research, arrays thereof, and methods of making said tissues and arrays.
Claims18
An in vitro method of producing a living, three-dimensional tissue construct comprising:
- a. bioprinting at least one semi-solid or solid bio-ink comprising endothelial cells and a different cell type in the same or separate bio-inks;
- and
- b. incubating the at least one semi-solid or solid bio-ink in vitro to cohere and form the living, three-dimensional tissue construct comprising a microvascular network consisting of endothelial cells that is located within the construct and is surrounded by cells that are not part of the microvascular network;
- wherein the tissue construct does not comprise an artery or vein.
1 more element
Dependencies are inferred from the claim text.