US 12,371,727 B2 · Microorganisms and methods for the continuous co-production of tandem repeat proteins and chemical products from C1-substrates

Abstract

Microorganisms are genetically engineered to continuously co-produce amino acids, proteins, microbial biomass, chemicals, or any combination thereof by microbial fermentation, particularly by microbial fermentation of a gaseous substrate. The microorganisms are C1-fixing. The production of ethylene, microbial biomass, and heterologous tandem repeat proteins can be improved. This can be effected by improved promoters or nutrient limiting means.

Claims13

Dependent claims

A genetically engineered microorganism capable of co-producing at least one heterologous protein, at least one chemical product, and microbial biomass from a gaseous substrate through a gas fermentation process, wherein the at least one heterologous protein is squid ring teeth (SRT) protein having at least 85% sequence identity to an amino acid sequence selected from the following SEQ ID No:

1, SEQ ID. No:
2, and SEQ ID No:
3, and wherein the microorganism is selected from Clostridium and Cupriavidus bacteria.

Dependencies are inferred from the claim text.

Microorganisms and methods for the continuous co-production of tandem repeat proteins and chemical products from C1-substrates

Life of this patent

Microorganisms and methods for the continuous co-production of tandem repeat proteins and chemical products from C1-substrates

Life of this patent

Abstract

Claims13