Genetic data compression and methods of use

A method of producing a plurality of genetically modified multi-cellular organisms, comprising:

• injecting a nucleic acid molecule comprising a plurality of index sequences into a cell of a single multi-cellular organism, the cell comprising a genomic polynucleotide comprising a synthetic landing pad, to produce a cell comprising the genomic polynucleotide comprising the synthetic landing pad and the nucleic acid molecule comprising the plurality of index sequences, wherein each of the plurality of index sequences comprises a first portion of a nucleotide sequence and is flanked by homology arms, and the synthetic landing pad comprises a second portion of the nucleotide sequence;
• generating a plurality of progeny multi-cellular organisms from the multi-cellular organism, wherein each of the plurality of progeny multi-cellular organisms comprises the genomic polynucleotide comprising the synthetic landing pad and the nucleic acid molecule comprising the plurality of index sequences;
• integrating a single index sequence of the plurality of index sequences into the synthetic landing pad in each of the plurality of progeny multi-cellular organisms, thereby linking the first and second portions of the nucleotide sequence;
• and
• selecting progeny multi-cellular organisms each comprising a single integrated index sequence based on presence or activity of the linked first and second portions of the nucleotide sequence, thereby producing a plurality of genetically modified multi-cellular organisms wherein the multi-cellular organism is C. elegans.