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US 12,371,689 B2Granted
Engineered enveloped vectors and methods of use thereof
AssigneeGigaMune, Inc.
InventorsDavid Scott Johnson, Matthew James Spindler, Robert Edgar, Yoong Wearn Lim, Taylor Weller
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Abstract
The present disclosure relates to a novel, engineered enveloped vector that can be used for gene delivery. The engineered enveloped vector comprises an engineered envelope comprising: (a) a viral envelope protein and optionally, (b) a non-viral membrane-bound protein. The present disclosure also provides a method of making and using the engineered enveloped vector.
Claims16
An engineered lentivirus comprising an envelope, wherein the envelope comprises:
- (a) a viral envelope protein having at least 90% sequence identity to a sequence selected from SEQ ID NOs:
- 1-167 or SEQ ID NOs:
- 8154-16497;
- (b) a non-viral membrane-bound protein comprising:
- (i) an optional signal peptide(S),
- (ii) an extracellular targeting domain (ETD), and
- (iii) a membrane-bound domain (MBD);
- and
- (c) a functional modulator protein,
- wherein the functional modulator protein is different from the non-viral membrane-bound protein and is capable of binding to a target cell to modulate a function of the target cell.
7 more elements
Dependencies are inferred from the claim text.