Back to results
US 12,371,674 B2Granted
Enone reductases
AssigneeCodexis, Inc.
InventorsChristopher K. Savile, Vesna Mitchell, Xiyun Zhang, Gjalt W. Huisman
Life of this patent
Estimating the term…
Abstract
The disclosure relates to engineered enone reductase polypeptides having improved properties, polynucleotides encoding the engineered polypeptides, related vectors, host cells, and methods for making the engineered enone reductase polypeptides. The disclosure also provides methods of using the engineered enone reductase polypeptides for chemical transformations.
Claims12
An enone reductase polypeptide comprising an amino acid sequence that is at least 80% identical to SEQ ID NO:
- 8;
- and wherein the amino acid sequence comprises one or more residue differences as compared to SEQ ID NO:
- 8 selected from the group consisting of:
- residue corresponding to X83 is L, R, V, I, K, E, or M;
- residue corresponding to X295 is T, or G;
- and residue corresponding to X296 is G, F, A, S, R, E, Q, K, or I.
3 more elements
Dependencies are inferred from the claim text.