Nucleoside modified mRNA and uses thereof
AssigneesBoston Medical Center Corporation, The Trustees of the University of Pennsylvania
InventorsValerie Gouon-Evans, Drew Weissman, Norbert Pardi
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Abstract
The present application discloses compositions and methods for use of nucleoside modified mRNA that encode for at least one liver regenerative factor. The present invention also relates to compositions and methods for use of nucleoside modified mRNA complexed to nanoparticles. The disclosed compositions and methods are useful for treating acute liver diseases, chronic liver diseases, and/or acetaminophen (acetyl-para-aminophenol, APAP) overdose.
Claims22
A composition comprising at least one engineered liver regenerative factor mRNA, the at least one engineered liver regenerative factor mRNA comprising a Vascular Endothelial Growth Factor A (VEGFA)-encoding nucleotide sequence having at least 95% sequence identity to the nucleotide sequence set forth in SEQ ID NO:
- 12.
Dependencies are inferred from the claim text.