Dual-phase zwitterionic monomers
AssigneeEnvision Biomedical LLC
InventorsJay Friedrich Künzler, Siddhesh Pawar
Life of this patent
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Abstract
Hydrogel materials used in the manufacture of biocompatible medical devices, for example, hydrogel materials having desirable physical properties for use as a contact lens. A composition contains at least one vinyl containing monomer, a methacrylate(acrylate) monomer, methacrylate (acrylate) prepolymers, crosslinking agents and monomers having the structure as shown in Formula 1: where R1 is a vinyl functionality capable of radical polymerization with specific preference for N-vinyl lactam derivatives and R2 is a zwitterionic functionality. The materials utilize a two-phase polymerization strategy.
Claims10
A contact lens prepared with a hydrogel polymer made from a composition comprising a monomer having the structure as shown in Formula (I):
- wherein:
- R1 is:
- wherein Y1 and Y2 are independent of one other and each on of Y1 and Y2 is a linkage selected from the group consisting of a direct bond, C1-C6 divalent radical, O, NRa, C(O), C(O)NRa, NRaC(O), OC(O)NH, NHC(O)O, NRaC(O)NH, NHC(O)NRa, C(O)O, OC(O), NHC(O)NHZ0—NH—C(O)NH, OC(O)NHZ0—NH—C(O)O, OC(O)NHZ0—NH—C(O)NH, and NHC(O)NHZ0—NH—C(O)O;
- where Ra is H, C1-C4 alkyl or C1-C3 alkanol, and Z0 is a linear or branched C2-C12 alkylene divalent radical, or a C5-C7 cycloaliphatic divalent radical;
- wherein Z2 is selected from the group consisting of a direct bond, a C1-C12 unsubstituted or substituted, linear or branched alkylene divalent radical, an unsubstituted phenylene divalent radical, a C5-C7 cycloaliphatic divalent radical, and a C7-C12 arylalkylene divalent radical,
- wherein at least two of the groups Y1, Y2, and Z2 is not a direct bond,
- wherein R2 is selected from the following anionic groups to provide a zwitterionic monomer capable of cyclo-copolymerizing:
- where R is selected from the group consisting of a direct bond, C1-C6 divalent radical, O, NRa, C(O), C(O)NRa, NRaC(O), OC(O)NH, NHC(O)O, NRaC(O)NH, NHC(O)NRa, C(O)O, OC(O), NHC(O)NHZ0—NH—C(O)NH, OC(O)NHZ0—NH—C(O)O, OC(O)NHZ0—NH—C(O)NH, and NHC(O)NHZ0—NH—C(O)O;
- where Ra is H, C1-C4 alkyl or C1-C3 alkanol, and Z0 is a linear or branched C2-C12 alkylene divalent radical, or a C5-C7 cycloaliphatic divalent radical.
Dependencies are inferred from the claim text.