Il-7R-alpha specific antibodies for treating acute lymphoblastic leukemia
AssigneesThe United States of America, as represented by the Secretary, Department of Health and Human Services, University of Maryland, College Park
InventorsScott Durum, Julie Hixon, Wen Qing Li, Scott Walsh, Lila Kashi
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Abstract
Antibodies and antigen binding fragments that specifically bind to IL-7Rα are disclosed. Nucleic acids encoding the antibodies and antigen binding fragments, and vectors including the nucleic acid molecules are also provided. Methods for detecting a ca cancer or a cell that expresses IL-7Rα using the antibodies and antigen binding fragments are disclosed, as is the use of the antibodies and antigen binding fragments to prevent and/or treat a subject with a cancer that expresses IL-7Rα, such as acute lymphoblastic leukemia.
Claims24
A method of treating a subject with an IL-7Rα positive cancer, comprising:
- administering to the subject a therapeutically effective amount of:
- (A) a monoclonal antibody that specifically binds to an extracellular domain of IL-7Rα, the monoclonal antibody comprising:
- a heavy chain variable region (VH) comprising a heavy chain complementarity determining region (HCDR)1, a HCDR2, and a HCDR3 of the VH set forth as SEQ ID NO:
- 1 (4A10 VH) and a light chain variable region (VL) comprising a light chain complementarity determining region (LCDR)1, a LCDR2, and a LCDR3 of the VL set forth as SEQ ID NO:
- 2 (4A10 VL), or
- a VH comprising a HCDR1, a HCDR2, and a HCDR3 of the VH set forth as SEQ ID NO:
- 3 (2B8 VH) and a VL comprising a LCDR1, a LCDR2, and a LCDR3 of the VL set forth as SEQ ID NO:
- 4 (2B8 VL);
- (B) an antigen binding fragment of the monoclonal antibody;
- (C) a bispecific antibody comprising the monoclonal antibody or the antigen binding fragment;
- or (D) an antibody-drug conjugate comprising the monoclonal antibody or the antigen binding fragment of the monoclonal antibody thereby treating the IL-7Rα positive cancer in the subject, wherein the IL-7Rα positive cancer is a solid tumor.
Dependencies are inferred from the claim text.