Anti-elastin antibodies and methods of use
AssigneeClemson University Research Foundation
InventorsNarendra R. Vyavahare, Charles D. Rice, Nasim Nosoudi, Saketh Karamched, Vaideesh Parasaram
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Abstract
Antibodies and antigen binding fragments thereof that specifically recognize and bind an epitope of elastin that is exposed and accessible in degraded elastic fiber are described. The antibodies and/or antigen binding fragments can be operably linked to a secondary component, including biologically active agents such as therapeutics and/or imaging agents. Optionally, the antibodies and/or antigen binding fragments thereof can be attached to a surface of a carrier, such as a particle, for specific binding and delivery of the carried agents to degraded elastic fiber.
Claims20
An antibody or antigen binding fragment thereof which binds to degraded elastin, the antibody or antigen binding fragment thereof comprising the amino acid sequence of SEQ ID NO:
- 9, SEQ ID NO:
- 11, SEQ ID NO:
- 13, SEQ ID NO:
- 27, SEQ ID NO:
- 29, and SEQ ID NO:
- 31.
Dependencies are inferred from the claim text.