Nemo coiled coil mimics and methods of using same
AssigneesNew York University, Cornell University
InventorsParamjit S. Arora, Ethel Cesarman, Michael G. Wuo, Jouliana Sadek
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Abstract
This invention relates to macrostructures (and pharmaceutical formulations containing them) that include a parallel coiled-coil structure, wherein the parallel coiled-coil comprises a first coil of Formula I and a second coil of Formula II: T1-f0-g0-a1-b1-c1-d1-e1-f1-g1-a2-b2-c2-d2-e2-f2-g2-a3-b3-c3-d3-e3-T2 (I) T3-g′0-a′1-b′1-c′1-d′1-e′1-f′1-g′1-a′2-b′2-c′2-d′2-e′2-f′2-g′2-a′3-b′3-c′3-d′3-e′3-f′3-T4 (II), as described in the present application. Methods of using these macrostructures are also disclosed.
Claims10
A method of inhibiting interaction between NEMO and a target molecule that binds to a helix dimer consisting of HLX1 and HLX2 of NEMO, said method comprising:
- contacting NEMO and/or the target molecule with a macrostructure comprising a parallel coiled-coil selected from the group consisting of CHD1NEMO, CHD2NEMO, CHD3NEMO, and CHD4NEMO under conditions effective to inhibit interaction between NEMO and the target molecule, wherein the target molecule is vFLIP.
Dependencies are inferred from the claim text.