Sapovirus vaccines
AssigneeVst LLC
InventorAlan John Young
Life of this patent
Estimating the term…
Abstract
The present invention describes immunogenic compositions containing immunogenic polypeptides of Sapovirus, including immunogenic compositions containing antigens other than Sapovirus antigens, including antigens that may be used in immunization against pathogens that cause diarrheal diseases. Methods of eliciting an immune response with the immunogenic compositions as disclosed and methods of treating a Sapovirus infection are also described.
Claims18
A method for producing Sapovirus-derived immunogenic polypeptides and/or peptides comprising:
- culturing a host cell transformed with a nucleic acid under conditions which induce expression of said polypeptides and/or peptides, wherein the polypeptides and/or peptides comprise an amino acid sequence as set forth in the group consisting of SEQ ID NO:2, SEQ ID NO:8, SEQ ID NO:15, SEQ ID NO:21 and combinations thereof, and optionally mixing or co-expressing said immunogenic polypeptides and/or peptides with one or more adjuvants.
An immunogenic composition comprising a polypeptide selected from the group consisting of SEQ ID NO:
- 2, SEQ ID NO:8, SEQ ID NO:15, SEQ ID NO:21 and combinations thereof.
An isolated recombinant nucleic acid encoding a Sapovirus VP1 protein, wherein the encoding nucleic acid comprises a sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:7, SEQ ID NO:14, SEQ ID NO:20, and combinations thereof.
Dependencies are inferred from the claim text.