Siderophore cephalosporin conjugates and uses thereof

A method of treating a bacterial infection in a subject in need thereof, comprising administering an effective amount of a compound according to formula (I)

• to the subject, wherein
• X is selected from the group consisting of CH, CCl and N,
• Z is selected from the group consisting of CH2COOH, CH(CH3)COOH, C(CH3)2COOH and CH2F,
• D is a single bond connecting A and Ar or selected from the group consisting of CO, NHCO and N(C0-6)alkyl-CO,
• A is selected from the group consisting of
• a (C1-6)alkanediyl and
• a (C3-6)cycloalkanediyl or,
• if D is N(C0)alkyl-CO, A forms a 4- to 7-membered aliphatic heterocyclic ring with the nitrogen atom of N(C0)alkyl-CO in D, and
• Ar is a 6-membered aromatic ring with a first hydroxyl group in para-position to D, a second hydroxyl group in meta-position to D, and with at least one electron-withdrawing element, and wherein the subject has the bacterial infection.