Mitochondrial activity inhibitors targeting tumoral metabolism

A method for inhibiting mitochondrial complex I, comprising administering to a patient in need thereof an effective amount of a compound of formula (I) as follows:

• wherein
• X1 and X2, identical or different, are NR5 or a sulfur atom, and at least one of X1 and X2 is a sulfur atom,
• Y is a group (C1-C10) alkanediyl,
• Ar1 and Ar2, identical or different, are each a naphthyl group optionally substituted by one or several groups selected from a halogen atom, a (C1-C6) alkyl, —OR1, —NR1R2 and —COOR3,
• with R1 and R2, independently of each other, are a hydrogen atom, a (C1-C6) alkyl group or a —COR4 group,
• R3 and R4, independently of each other, are a hydrogen atom or a (C1-C6) alkyl group, and
• R5 is a hydrogen atom or a (C1-C6) alkyl group,
• or a pharmaceutically acceptable salt and/or solvate thereof or a composition comprising said compound of formula (I) and at least one pharmaceutically acceptable excipient.