Dithienyl disulfiram derivatives as selective ALDH1A1 inhibitors
AssigneeBatterjee Medical College
InventorsZiad Omran, Omeima Abdullah
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Abstract
A method of selectively inhibiting aldehyde dehydrogenase 1a1 (ALDH1a1) relative to aldehyde dehydrogenase 2 (ALDH2) in a subject may include administering to the subject in need thereof, an effective amount of a disulfiram derivative having a structure which may be substituted and is optionally a salt, solvate, tautomer, stereoisomer, or mixture thereof, thereby selectively inhibiting the ALDH1A1 relative to ALDH2 in the subject. An aldehyde dehydrogenase 1a1 (ALDH1a1)-selective antagonist composition, may include such a disulfiram derivative and a pharmaceutically acceptable carrier and/or excipient.
Claims22
An aldehyde dehydrogenase 1a1 (ALDH1a1)-selective antagonist composition, comprising:
- a pharmaceutically acceptable carrier and/or excipient;
- and
- a di-(3-thienylmethylene)-disulfiram derivative, which is optionally substituted, optionally as a salt, solvate, tautomer, stereoisomer, or mixture thereof.
A disulfiram derivative having a structure
- optionally in substituted form.
A method of selectively inhibiting aldehyde dehydrogenase 1a1 (ALDH1a1) relative to aldehyde dehydrogenase 2 (ALDH2) in a subject, the method comprising:
- administering to the subject in need thereof, an effective amount of a di-(3-thienylmethylene)-disulfiram derivative, which is optionally substituted, optionally as a salt, solvate, tautomer, stereoisomer, or mixture thereof, thereby selectively inhibiting the ALDH1A1 relative to ALDH2 in the subject.
Dependencies are inferred from the claim text.